Affective wellbeing moderates the association between polygenic risk score for neuroticism and change in neuroticism

Introduction Neuroticism has societal, mental and physical health relevance, with an etiology involving genetic predisposition, psychological influence, their interaction. Objectives To understand whether the association between polygenic risk score for neuroticism (PRS-N) is moderated by affective well-being. Methods Data were derived from TwinssCan, a general population twin cohort (age range=15-35 years, 478 monozygotic twins). Self-report questionnaires used to measure well-being neuroticism. PRS-N was trained Genetics of Personality Consortium (GPC) United Kingdom Biobank (UKB). Multilevel mixed-effects models test baseline changes in Results Baseline wellbeing associated (β=-1.35, p<0.001). PRSs-N (lowest p-value: 0.008 GPC, 0.01 UKB). In interaction (PRS x wellbeing), GPC (β=0.38, p=0.04) UKB (β=0.81, p<0.001) had significant interactions. 0.03 0.3 Furthermore, (β =-0.66, change only (β=0.80, Conclusions Interaction risk, neuroticism, observed regarding baselines measures over time. Depending on analysis step, direction effect changed. Disclosure Interest None Declared